血压随肾脏变化：围生期对遗传性高血压的影响。
Blood pressure follows the kidney: Perinatal influences on hereditary hypertension.
机构信息
Department of Nephrology and Hypertension; University Medical Center; Utrecht The Netherlands.
出版信息
Organogenesis. 2008 Jul;4(3):153-7. doi: 10.4161/org.4.3.6504.
Abstract
Epidemiological and experimental data strongly suggest that cardiovascular diseases can originate from an aberrant environment during fetal development, a phenomenon referred to as perinatal programming. This review will focus on the role of the kidneys in determining blood pressure, and how (re)programming the renal development can persistently ameliorate hereditary hypertension. By combining physiologic and genomic studies we have discovered some candidate pathways suited for (re)programming the development of hypertension. This sets the stage for mechanistic analysis in future studies.
摘要
流行病学和实验数据强烈表明，心血管疾病可能起源于胎儿发育过程中的异常环境，这种现象被称为围产期编程。这篇综述将重点讨论肾脏在确定血压方面的作用，以及（重新）编程肾脏发育如何持续改善遗传性高血压。通过结合生理学和基因组研究，我们已经发现了一些适合（重新）编程高血压发育的候选途径。这为未来研究中的机制分析奠定了基础。
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