Jones S K, Winter J G, Gray B N
Sirtex Medical Limited, North Ryde, NSW, Australia.
Int J Hyperthermia. 2002 Mar-Apr;18(2):117-28. doi: 10.1080/02656730110103519.
Experimental rabbit liver tumours were preferentially heated to therapeutic temperatures without compromising the surrounding normal hepatic parenchyma. This was achieved by the use of hepatic arterially infused ferromagnetic microspheres that heat as a result of magnetic hysteresis loss when exposed to an alternating magnetic field. Treatment sessions involving a single 20-min exposure to the alternating field resulted in total suppression of tumour growth at 14 days compared to controls, in which tumour sizes increased dramatically over the same period. Histopathological examination of treated tumour sections showed total tumour destruction in some cases. Separate animal groups used to control for the effects of the embolized microspheres alone and for the effect of the applied magnetic field yielded similar tumour growth responses to a control group with no intervention whatsoever. The achievement of positive temperature differentials between tumour and normal liver and the consequent therapeutic responses encourages further development of this technology for the treatment of liver cancer in humans.
实验性兔肝肿瘤被优先加热到治疗温度，而不损害周围正常肝实质。这是通过使用经肝动脉注入的铁磁微球实现的，当暴露于交变磁场时，这些微球会因磁滞损耗而发热。与对照组相比，单次20分钟暴露于交变磁场的治疗疗程在14天时导致肿瘤生长完全受到抑制，而在同一时期，对照组肿瘤大小急剧增加。对治疗后的肿瘤切片进行组织病理学检查，在某些情况下显示肿瘤完全破坏。用于单独控制栓塞微球的影响以及施加磁场的影响的不同动物组，其肿瘤生长反应与未进行任何干预的对照组相似。肿瘤与正常肝脏之间实现正温差以及随之而来的治疗反应，促使该技术进一步发展用于人类肝癌的治疗。
