Jiang Kaiyi, Zhang Linlin, Bao Gang
Department of Bioengineering, Rice University, Houston, TX 77030.
Curr Opin Biomed Eng. 2021 Dec;20. doi: 10.1016/j.cobme.2021.100330. Epub 2021 Aug 17.
Owing to the quantum confinement at the nanoscale, magnetic iron oxide nanoparticles (MIONs) consisting of magnetite and maghemite nanocrystals have unique physical properties, enabling a wide range of biomedical applications by utilizing mechanical, magnetic, chemical, and thermal effects of MIONs respectively. For example, MIONs can serve as a contrast agent for magnetic resonance imaging (MRI), convert electromagnetic energy into thermal energy for hyperthermia therapy, and carry drug/gene for targeted delivery. In this review, we discuss the recent development of MION based engineering approaches and their biomedical applications, including sensitive protein quantification, magnetic nanoparticle heating, molecular imaging, and drug delivery. The opportunities and challenges in further exploring the biomedical applications of MIONs are also briefly discussed.
由于纳米尺度的量子限制效应，由磁铁矿和磁赤铁矿纳米晶体组成的磁性氧化铁纳米颗粒（MIONs）具有独特的物理性质，分别利用MIONs的机械、磁、化学和热效应，使其在广泛的生物医学应用中得以实现。例如，MIONs可作为磁共振成像（MRI）的造影剂，将电磁能转化为热能用于热疗，并携带药物/基因进行靶向递送。在本综述中，我们讨论了基于MIONs的工程方法及其生物医学应用的最新进展，包括灵敏的蛋白质定量、磁性纳米颗粒加热、分子成像和药物递送。还简要讨论了进一步探索MIONs生物医学应用中的机遇与挑战。
