Burton M A, Kelleher D K, Codde J P, Gray B N
University of Western Australia, Department of Surgery, Royal Perth Hospital.
Int J Hyperthermia. 1991 Mar-Apr;7(2):271-7. doi: 10.3109/02656739109004996.
The influence of liver hyperthermia on hepatic arterial and portal venous blood flow to tumour and normal hepatic tissue was examined in a rabbit VX2 tumour model. Hyperthermia was delivered by 2450 MHz microwave generator to exteriorized livers in 18 rabbits. Blood flow was measured in both portal vein and hepatic artery using radioactive tracer microspheres before, during and 5 min after intense (greater than 43 degrees C) hyperthermia. During hyperthermia a decrease in total liver blood flow was composed primarily of a decrease in hepatic arterial blood flow to tumour tissue. Tumours were supplied almost exclusively by the hepatic artery and thus total tumour blood flow was significantly depressed during heating. The decreased tumour blood flow persisted after the cessation of hyperthermia and was indicative of vascular collapse in the tumour tissue. Temperature differentials in tumour compared to normal tissue ranged from 5 degrees C to 8 degrees C during hyperthermia because of the lower tumour blood flow. The portal vein exerted minimal influence on temperatures attained in the tumour tissue during hyperthermia but would have mediated normal liver tissue heat loss.
在兔VX2肿瘤模型中，研究了肝脏热疗对肿瘤及正常肝组织肝动脉和门静脉血流的影响。使用2450 MHz微波发生器对18只兔的外置肝脏进行热疗。在高强度（高于43℃）热疗前、热疗期间及热疗后5分钟，使用放射性示踪微球测量门静脉和肝动脉的血流。热疗期间，肝脏总血流量减少，主要是由于肿瘤组织肝动脉血流减少。肿瘤几乎完全由肝动脉供血，因此加热期间肿瘤总血流量显著降低。热疗停止后，肿瘤血流量持续减少，表明肿瘤组织血管塌陷。由于肿瘤血流量较低，热疗期间肿瘤与正常组织的温差为5℃至8℃。热疗期间门静脉对肿瘤组织达到的温度影响最小，但会介导正常肝组织的热量散失。
