Patrick M H
Basic Life Sci. 1975;5A:205-8. doi: 10.1007/978-1-4684-2895-7_26.
The action of an endonuclease from Micrococcus luteus that operates on UV damage in DNA overlaps with that of DNA photolyase from yeast: homo- and heterocyclobutane dipyrimidines in DNA are substrates for both enzymes, but pyrimidine adducts or the "spore photoproduct" in DNA are not. As expected from this overlap, the action of the two enzymes is mutually interfering: single-strand nicks introduced by the endonuclease effectively preclude photoreactivation; conversely, formation of a photolyase-cyclobutane dipyrimidine complex can prevent nicking by the endonuclease.
藤黄微球菌中一种作用于DNA紫外线损伤的核酸内切酶的作用，与酵母中的DNA光解酶的作用重叠：DNA中的同型和杂环丁烷二嘧啶是这两种酶的底物，但DNA中的嘧啶加合物或“孢子光产物”则不是。从这种重叠可以预期，这两种酶的作用相互干扰：核酸内切酶引入的单链切口有效地阻止了光复活；相反，光解酶-环丁烷二嘧啶复合物的形成可以防止核酸内切酶产生切口。
