光复活作用：紫外线诱导细胞转化中嘧啶二聚体的评估
Photoreactivation: evaluation of pyrimidine dimers in ultraviolet radiation-induced cell transformation.
作者信息
Sutherland B M
出版信息
Natl Cancer Inst Monogr. 1978 Dec(50):129-32.
PMID:753970
Abstract
The PRE repairs DNA by the specific and exclusive monomerization of pyrimidine dimers. Photoreactivation thus provides an analytical test for determining the role of pyrimidine dimers in UV damage to biologic systems. We have shown the first UV transformation of cultured human cells (judged by ability to grow in soft agar). Preliminary results indicate that 1) lesions leading to cell transformation are subject to photoreactivation and 2) pyrimidine dimers may well be important in solar carcinogenesis.
摘要
光复活酶通过嘧啶二聚体的特异性和排他性单体化来修复DNA。因此，光复活作用为确定嘧啶二聚体在紫外线对生物系统损伤中的作用提供了一种分析测试方法。我们已经展示了培养的人类细胞的首次紫外线转化（通过在软琼脂中生长的能力来判断）。初步结果表明：1）导致细胞转化的损伤可进行光复活；2）嘧啶二聚体很可能在阳光致癌过程中起重要作用。
Zotero 插件