从调控信号预测甲硫腺苷循环中的基因功能。
Prediction of gene function in methylthioadenosine recycling from regulatory signals.
作者信息
Murphy Brooke A, Grundy Frank J, Henkin Tina M
机构信息
Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, USA.
出版信息
J Bacteriol. 2002 Apr;184(8):2314-8. doi: 10.1128/JB.184.8.2314-2318.2002.
Abstract
The S-box transcription termination control system, first identified in Bacillus subtilis, is used for regulation of gene expression in response to methionine availability. The presence of the S-box motif provided the first indication that the ykrTS and ykrWXYZ genes could play a role in recycling of 5'-methylthioadenosine, a by-product of polyamine biosynthesis that can be converted to methionine. In this study we demonstrate a role for the ykrTS and ykrWXYZ gene products in this pathway.
摘要
S-box转录终止控制系统最初是在枯草芽孢杆菌中发现的，用于响应蛋氨酸的可利用性来调节基因表达。S-box基序的存在首次表明，ykrTS和ykrWXYZ基因可能在5'-甲硫基腺苷的循环利用中发挥作用，5'-甲硫基腺苷是多胺生物合成的一种副产物，可转化为蛋氨酸。在本研究中，我们证明了ykrTS和ykrWXYZ基因产物在该途径中的作用。
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