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双组分信号转导系统的EvgA调节大肠杆菌中yhiUV多药转运蛋白的产生。

EvgA of the two-component signal transduction system modulates production of the yhiUV multidrug transporter in Escherichia coli.

作者信息

Nishino Kunihiko, Yamaguchi Akihito

机构信息

Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki-shi, Osaka 567-0047, Japan.

出版信息

J Bacteriol. 2002 Apr;184(8):2319-23. doi: 10.1128/JB.184.8.2319-2323.2002.

DOI:10.1128/JB.184.8.2319-2323.2002
PMID:11914367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC134960/
Abstract

Overexpression of the EvgA regulator of the two-component signal transduction system was previously found to modulate multidrug resistance of Escherichia coli by increasing efflux of drugs (K. Nishino and A. Yamaguchi, J. Bacteriol. 183:1455-1458, 2001). Here we present data showing that EvgA contributes to multidrug resistance through increased expression of the multidrug transporter yhiUV gene.

摘要

先前发现双组分信号转导系统的EvgA调节因子的过表达通过增加药物外排来调节大肠杆菌的多药耐药性（K. Nishino和A. Yamaguchi，《细菌学杂志》183:1455 - 1458，2001年）。在此我们展示的数据表明，EvgA通过增加多药转运蛋白yhiUV基因的表达来促进多药耐药性。

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EvgA of the two-component signal transduction system modulates production of the yhiUV multidrug transporter in Escherichia coli.双组分信号转导系统的EvgA调节大肠杆菌中yhiUV多药转运蛋白的产生。
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本文引用的文献

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Analysis of a complete library of putative drug transporter genes in Escherichia coli.大肠杆菌中假定药物转运蛋白基因完整文库的分析。
J Bacteriol. 2001 Oct;183(20):5803-12. doi: 10.1128/JB.183.20.5803-5812.2001.
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Novel macrolide-specific ABC-type efflux transporter in Escherichia coli.大肠杆菌中新型大环内酯特异性ABC型外排转运蛋白。
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Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes.缺乏多药外排泵基因的大肠杆菌菌株的抗生素敏感性谱
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4
Overexpression of the response regulator evgA of the two-component signal transduction system modulates multidrug resistance conferred by multidrug resistance transporters.双组分信号转导系统的应答调节子EvgA的过表达可调节多药耐药转运蛋白赋予的多药耐药性。
J Bacteriol. 2001 Feb;183(4):1455-8. doi: 10.1128/JB.183.4.1455-1458.2001.
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Molecular properties of bacterial multidrug transporters.细菌多药转运蛋白的分子特性
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Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.铜绿假单胞菌PAO1（一种机会致病菌）的全基因组序列
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Transcription of emrKY is regulated by the EvgA-EvgS two-component system in Escherichia coli K-12.在大肠杆菌K-12中，emrKY的转录受EvgA-EvgS双组分系统调控。
Biosci Biotechnol Biochem. 2000 Jun;64(6):1203-9. doi: 10.1271/bbb.64.1203.
9
Cross-linked complex between oligomeric periplasmic lipoprotein AcrA and the inner-membrane-associated multidrug efflux pump AcrB from Escherichia coli.来自大肠杆菌的寡聚周质脂蛋白AcrA与内膜相关多药外排泵AcrB之间的交联复合物。
J Bacteriol. 2000 Aug;182(15):4264-7. doi: 10.1128/JB.182.15.4264-4267.2000.
10
Dimerization of signalling modules of the EvgAS and BvgAS phosphorelay systems.EvgAS和BvgAS磷酸化信号转导系统信号模块的二聚化
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