Frisch B, Lewis S M, Sherman D
Br J Haematol. 1975 Apr;29(4):545-52. doi: 10.1111/j.1365-2141.1975.tb02741.x.
Electron microscopy of erythropoiesis in aplastic anaemia has demonstrated some unique features of dyserythropoiesis at the ultrastructural level, which contribute to understanding of the morphological features which are seen in the light microscope. The findings provide further evidence for the presence of qualitative defects in erythropoiesis in aplastic conditions. The alterations seen included bi- and multinucleated cells, intercellular bridges containing microtubules, internuclear chromatin bridges, irregular nuclear shapes, juxta-nuclear and peripheral cisternal structures, ringed sideroblasts, a diversity of intranuclear inclusions, nuclear clefts in both eu- and heterochromatin, and a variety of anomalies of the nuclear membrane. The significance of the occurrence of these anomalies in aplastic anaemia is considered and the role of the nuclear membrane and of endoplasmic reticulum in the pathogenesis of aplastic anaemia is discussed.
再生障碍性贫血中红细胞生成的电子显微镜检查已在超微结构水平上显示了发育异常红细胞生成的一些独特特征，这有助于理解光学显微镜下所见的形态学特征。这些发现为再生障碍性贫血状态下红细胞生成存在质量缺陷提供了进一步证据。观察到的改变包括双核和多核细胞、含有微管的细胞间桥、核间染色质桥、不规则核形状、近核和周边池状结构、环形铁粒幼细胞、多种核内包涵体、常染色质和异染色质中的核裂以及核膜的各种异常。文中考虑了这些异常在再生障碍性贫血中发生的意义，并讨论了核膜和内质网在再生障碍性贫血发病机制中的作用。
