Rozman C, Feliu E, Granena A, Brugues R, Woessner S, Vives Corrons J L
Br J Haematol. 1982 Jan;50(1):63-73. doi: 10.1111/j.1365-2141.1982.tb01891.x.
Transmission electron microscopy was used to examine marrow samples from 15 patients with aplastic anaemia or acute leukaemia who had been treated with bone marrow transplantation. There were 11 allogeneic, three syngeneic and one autologous graft. The purpose was to estimate the frequency, type and extent of dyserythropoietic change. Transient dyserythropoietic features were substantiated in all cases. Nuclear changes were present in 12 cases, iron laden mitochondria (sideroachrestic phenomena) in 10 and cytoplasmic contacts and/or connections between red cell precursors in 10. Dyserythropoiesis was most conspicuous in the majority of cases between 14 and 28 d after transplantation but it may persist for over 100 d. No deficit in red cell production was noted and it is proposed that dyserythropoiesis in this circumstance is a physiological rather than a pathological phenomenon.
采用透射电子显微镜检查了15例接受过骨髓移植治疗的再生障碍性贫血或急性白血病患者的骨髓样本。其中有11例同种异体移植、3例同基因移植和1例自体移植。目的是评估红细胞生成异常变化的频率、类型和程度。所有病例均证实存在短暂的红细胞生成异常特征。12例出现核变化，10例出现含铁线粒体（铁粒幼细胞现象），10例出现红细胞前体细胞之间的细胞质接触和/或连接。红细胞生成异常在移植后14至28天的大多数病例中最为明显，但可能持续超过100天。未发现红细胞生成不足，因此提出在这种情况下的红细胞生成异常是一种生理而非病理现象。
