Mittendorfer B, Klein S
Center for Human Nutrition and Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Int J Sport Nutr Exerc Metab. 2001 Dec;11 Suppl:S86-91. doi: 10.1123/ijsnem.11.s1.s86.
Endurance exercise increases the use of endogenous fuels to provide energy for working muscles. Elderly subjects oxidize more glucose and less fat during moderate intensity exercise. This shift in substrate use is presumably caused by age-related changes in skeletal muscle, including decreased skeletal muscle respiratory capacity, because adipose tissue lipolysis and plasma fatty acid availability are not rate limiting. Endurance training in elderly subjects increases muscle respiratory capacity, decreases glucose production and oxidation, and increases fat oxidation thereby correcting or compensating for the alterations in substrate oxidation associated with aging.
耐力运动增加内源性燃料的利用，为工作中的肌肉提供能量。老年受试者在中等强度运动期间氧化更多的葡萄糖和更少的脂肪。底物利用的这种转变可能是由骨骼肌中与年龄相关的变化引起的，包括骨骼肌呼吸能力下降，因为脂肪组织脂解和血浆脂肪酸可用性并非限速因素。对老年受试者进行耐力训练可增加肌肉呼吸能力，减少葡萄糖生成和氧化，并增加脂肪氧化，从而纠正或补偿与衰老相关的底物氧化改变。
