心肺适能对与年龄相关的脂质和脂蛋白的影响。
The effect of cardiorespiratory fitness on age-related lipids and lipoproteins.
作者信息
Park Yong-Moon Mark, Sui Xuemei, Liu Junxiu, Zhou Haiming, Kokkinos Peter F, Lavie Carl J, Hardin James W, Blair Steven N
机构信息
Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.
Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.
出版信息
J Am Coll Cardiol. 2015 May 19;65(19):2091-100. doi: 10.1016/j.jacc.2015.03.517.
BACKGROUND
Evidence on the effect of cardiorespiratory fitness (CRF) on age-related longitudinal changes of lipids and lipoproteins is scarce.
OBJECTIVES
This study sought to assess the longitudinal aging trajectory of lipids and lipoproteins for the life course in adults and to determine whether CRF modifies the age-associated trajectory of lipids and lipoproteins.
METHODS
Data came from 11,418 men, 20 to 90 years of age, without known high cholesterol, high triglycerides, cardiovascular disease, and cancer at baseline and during follow-up from the Aerobics Center Longitudinal Study. There were 43,821 observations spanning 2 to 25 health examinations (mean 3.5 examinations) between 1970 and 2006. CRF was quantified by a maximal treadmill exercise test. Marginal models using generalized estimating equations were applied.
RESULTS
Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, and non-high-density lipoprotein cholesterol (non-HDL-C) presented similar inverted U-shaped quadratic trajectories with aging: gradual increases were noted until age mid-40s to early 50s, with subsequent declines (all p < 0.0001). Compared with men with higher CRF, those with lower CRF developed abnormal values earlier in life: TC (≥200 mg/dl), LDL-C (≥130 mg/dl), non-HDL-C (≥160 mg/dl), and triglycerides/HDL-C ratio (≥3.0). Notably, abnormal values for TC and LDL-C in men with low CRF were observed around 15 years earlier than in those with high CRF. After adjusting for time-varying covariates, a significant interaction was found between age and CRF in each trajectory, indicating that CRF was more strongly associated with the aging trajectories of lipids and lipoproteins in young to middle-age men than in older men.
CONCLUSIONS
Our investigation reveals a differential trajectory of lipids and lipoproteins with aging according to CRF in healthy men and suggests that promoting increased CRF levels may help delay the development of dyslipidemia.
背景
关于心肺适能（CRF）对脂质和脂蛋白与年龄相关的纵向变化影响的证据很少。
目的
本研究旨在评估成年人一生中脂质和脂蛋白的纵向衰老轨迹，并确定CRF是否会改变脂质和脂蛋白与年龄相关的轨迹。
方法
数据来自有氧运动中心纵向研究中11418名20至90岁的男性，他们在基线和随访期间均无已知的高胆固醇、高甘油三酯、心血管疾病和癌症。在1970年至2006年期间，共有43821次观察，涵盖2至25次健康检查（平均3.5次检查）。CRF通过最大跑步机运动试验进行量化。应用了使用广义估计方程的边际模型。
结果
总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯和非高密度脂蛋白胆固醇（non-HDL-C）随着年龄增长呈现出相似的倒U形二次轨迹：在40多岁中期到50岁出头之前逐渐升高，随后下降（所有p<0.0001）。与CRF较高的男性相比，CRF较低的男性在生命早期就出现了异常值：TC（≥200mg/dl）、LDL-C（≥130mg/dl）、non-HDL-C（≥160mg/dl）和甘油三酯/HDL-C比值（≥3.0）。值得注意的是，CRF较低的男性中TC和LDL-C的异常值比CRF较高的男性早约15年出现。在调整了随时间变化的协变量后，在每个轨迹中发现年龄和CRF之间存在显著的相互作用，表明与老年男性相比，CRF与年轻至中年男性脂质和脂蛋白的衰老轨迹的关联更强。
结论
我们的调查揭示了健康男性中根据CRF不同的脂质和脂蛋白随年龄变化的轨迹，并表明促进CRF水平升高可能有助于延缓血脂异常的发展。
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