Kovalev G V, Morozov I S
Biull Eksp Biol Med. 1975 Apr;79(4):71-5.
Experiments were conducted on decerebrated cats. A depressive effect of gamma-aminobutyruc acid (GABA)--100--200 mg/kg and its phenyl derivative phenibut--20 mg/kg--on depressive reactions of the systemic arterial pressure and on the inhibition of spontaneous bioelectrical activity in the renal nerve occurring in stimulation of the mechanoreceptors of the carotid sinus and of the sinus and depressor nerve afferents (having a mechanoreceptor modality) was demonstrated. Pressor reactions of the systemic arterial pressure and evoked bioelectrical activity were enhanced in the renal nerve in stimulation of chemoreceptors of the carotid sinus following administration of the same GABA and phenibut doses. The data obtained are interpreted from the aspect of a deprimating action of GABA and phenibut in the area of the paramedian reticular nuclei of the medulla oblongata.
实验在去大脑的猫身上进行。已证实，γ-氨基丁酸（GABA）——100——200毫克/千克及其苯基衍生物苯乙哌啶酮——20毫克/千克——对全身动脉压的抑郁反应以及对刺激颈动脉窦和窦神经及减压神经传入纤维（具有机械感受器模式）时肾神经自发生物电活动的抑制有抑制作用。在给予相同剂量的GABA和苯乙哌啶酮后，刺激颈动脉窦化学感受器时，全身动脉压的升压反应和肾神经中诱发的生物电活动增强。从GABA和苯乙哌啶酮在延髓旁正中网状核区域的抑制作用方面对所获得的数据进行了解释。
