Littbrand B, Edsmyr F, Révész L
Bull Cancer. 1975 Jul-Sep;62(3):241-8.
Experimental observations are described which form the basis of a low dose-fractionation scheme designed in an attempt to circumvent the problem presented for radiotherapy by the particular radioresistance of poorly oxygenated cells. In a preliminary investigation the scheme was tested in the treatment of carcinoma of the bladder. A total of 45 patients were included in the trial, randomized to be treated according to either of two fractionation schemes. Scheme I : 100 rad 3 times a day, 5 days a week, a total tumor dose of 8 400 rad, 2 weeks of rest in middle of the treatment period. Scheme II : 200 rad once a day, 5 days a week, a total tumor dose of 6 400 rad, 2 weeks of rest in the middle of the treatment period. The results suggest an improved therapeutic ratio with Scheme I in comparison to Scheme II.
本文描述了一些实验观察结果，这些结果构成了一种低分割放疗方案的基础，该方案旨在解决乏氧细胞的特殊放射抗性给放射治疗带来的问题。在一项初步研究中，该方案在膀胱癌治疗中进行了测试。共有45名患者纳入试验，随机分为两组，分别按照两种分割方案进行治疗。方案I：每天3次，每次100拉德，每周5天，肿瘤总剂量8400拉德，治疗期间中间休息2周。方案II：每天1次，每次200拉德，每周5天，肿瘤总剂量6400拉德，治疗期间中间休息2周。结果表明，与方案II相比，方案I的治疗比有所提高。
