Mancianti F, Pedonese F, Millanta F, Guarnieri L
Dipartimento di Patologia Animale, Profilassi ed Igiene degli Alimenti, Università di Pisa, Viale delle Piagge, 2, 56124 Pisa, Italy.
J Feline Med Surg. 1999 Mar;1(1):37-41. doi: 10.1016/S1098-612X(99)90008-6.
Microsporum canis is the dermatophyte most commonly responsible for ringworm in cats. The purpose of this paper was to evaluate the in vivo efficacy of oral terbinafine (Lamisil; Sandoz) in the treatment of feline ringworm caused by M canis, and to consider this drug as an alternative to griseofulvin or imidazoles. Fifteen cats infected with M canis were treated orally once daily with 30 mg/kg of terbinafine over a 2-week period. All treated animals were checked for dermatophytes on the last day of treatment, a month later and 3 months after the last administration of the drug. Only 12 cats could be used in the whole trial and 11 of these (92%) showed a complete cure. Terbinafine could be an effective alternative to griseofulvin when fungal resistance or idiosyncrasic intolerance are shown and, compared with griseofulvin, could give a faster rate of cure and less relapses.
犬小孢子菌是猫癣最常见的致病皮肤真菌。本文旨在评估口服特比萘芬（兰美抒；山德士公司）治疗犬小孢子菌引起的猫癣的体内疗效，并将该药视为灰黄霉素或咪唑类药物的替代药物。15只感染犬小孢子菌的猫在2周内每天口服一次30mg/kg的特比萘芬。在治疗的最后一天、一个月后以及最后一次给药后3个月，对所有治疗的动物进行皮肤真菌检查。整个试验中仅12只猫可用，其中11只（92%）完全治愈。当出现真菌耐药或特异质不耐受时，特比萘芬可能是灰黄霉素的有效替代药物，并且与灰黄霉素相比，治愈率更高且复发率更低。
