Aneke Chioma I, Otranto Domenico, Cafarchia Claudia
Dipartimento di Medicina Veterinaria, Università degli Studi "Aldo Moro", 70010 Valenzano, Bari, Italy.
Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka 410001, Nigeria.
J Fungi (Basel). 2018 Sep 5;4(3):107. doi: 10.3390/jof4030107.
is a worldwide diffused zoophilic dermatophyte which causes clinical conditions often characterised by multifocal alopecia, scaling, and circular lesions in many animal species, including humans. A large variety of oral and topical antifungal protocols is available for treating infection. However, the efficacy of these drugs and treatment protocols is variable, with treatment failure up to 40% of patients possibly due to resistance phenomena. The lack of standardised reference methods for evaluating the antifungal susceptibility of represents a major hindrance in assessing microbiological resistance in unresponsive clinical cases. Therefore, data about conventional therapy against and the protocols employed to test the antifungal activity of the most commonly employed drugs (i.e., azoles, polyenes, allylamines, and griseofulvin) have been summarised herein. This article focuses on technical parameters used for antifungal susceptibility tests, their effects on the minimum inhibitory concentration value, as well as their clinical implications.
是一种广泛传播的亲动物性皮肤癣菌，可导致多种临床症状，其特征通常为多灶性脱发、脱屑，以及在包括人类在内的许多动物物种中出现圆形皮损。有多种口服和外用抗真菌方案可用于治疗感染。然而，这些药物和治疗方案的疗效各不相同，高达40%的患者治疗失败可能是由于耐药现象。缺乏评估该菌抗真菌药敏性的标准化参考方法是评估无反应临床病例中微生物耐药性的主要障碍。因此，本文总结了关于针对该菌的传统疗法以及用于测试最常用药物（即唑类、多烯类、烯丙胺类和灰黄霉素）抗真菌活性的方案的数据。本文重点关注抗真菌药敏试验所使用的技术参数、它们对最低抑菌浓度值的影响及其临床意义。
