Soares Luciana Arantes, de Cássia Orlandi Sardi Janaína, Gullo Fernanda Patrícia, de Souza Pitangui Nayla, Scorzoni Liliana, Leite Fernanda Sangalli, Giannini Maria José Soares Mendes, Almeida Ana Marisa Fusco
Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista "Júlio Mesquita Filho", Araraquara, SP, Brazil.
Braz J Microbiol. 2014 Mar 10;44(4):1035-41. doi: 10.1590/S1517-83822014005000011. eCollection 2013 Dec.
Millions of people and animals suffer from superficial infections caused by a group of highly specialized filamentous fungi, the dermatophytes, which only infect keratinized structures. With the appearance of AIDS, the incidence of dermatophytosis has increased. Current drug therapy used for these infections is often toxic, long-term, and expensive and has limited effectiveness; therefore, the discovery of new anti dermatophytic compounds is a necessity. Natural products have been the most productive source for new drug development. This paper provides a brief review of the current literature regarding the presence of dermatophytes in immunocompromised patients, drug resistance to conventional treatments and new anti dermatophytic treatments.
数以百万计的人和动物遭受由一组高度专业化的丝状真菌——皮肤癣菌引起的浅表感染，这些真菌仅感染角质化结构。随着艾滋病的出现，皮肤癣菌病的发病率有所上升。目前用于这些感染的药物治疗往往有毒、疗程长且费用高，效果有限；因此，发现新的抗皮肤癣菌化合物是必要的。天然产物一直是新药开发最丰富的来源。本文简要综述了当前有关免疫功能低下患者中皮肤癣菌的存在、对传统治疗的耐药性以及新的抗皮肤癣菌治疗方法的文献。
