Kaufman H E
Ophthalmology. 1979 Jan;86(1):131-6. doi: 10.1016/s0161-6420(79)35550-6.
There are two antiviral agents that are commercially available for use in ocular herpes infections, idoxuridine, and vidarabine (Ara-A). In topical usage, these medications are similar in their effectiveness and toxicity; however, vidarabine is systemically active for treatment of deep ocular disease. Trifluorothymidine, which is still an experimental drug, has been shown in double-blind clinical trials to be the most potent antiviral drug for ocular use. These three antiviral drugs, however, are not truly selective in their action and interfere with normal cellular functions as well as virus synthesis. Several new drugs have been reported that are selective and are only effective in herpes virus infected cells; the most active of these compounds appears to be acycloguanosine.
有两种可用于眼部疱疹感染的抗病毒药物，即碘苷和阿糖腺苷（Ara - A）。局部使用时，这些药物在疗效和毒性方面相似；然而，阿糖腺苷对深部眼部疾病的治疗具有全身活性。三氟胸苷仍是一种实验性药物，在双盲临床试验中已表明它是最有效的眼部抗病毒药物。然而，这三种抗病毒药物在作用上并非真正具有选择性，它们会干扰正常细胞功能以及病毒合成。已报道了几种具有选择性且仅在疱疹病毒感染细胞中有效的新药；其中最具活性的化合物似乎是阿昔洛韦。
