实验性单纯疱疹性角膜炎的无环抗代谢物疗法。

Acyclic antimetabolite therapy of experimental herpes simplex keratitis.

作者信息

Pavan-Langston D, Campbell R, Lass J

出版信息

Am J Ophthalmol. 1978 Nov;86(5):618-23. doi: 10.1016/0002-9394(78)90178-2.

Abstract

In a masked controlled study we compared 3% acycloguanosine, 0.5% idoxuridine, and 3% vidarabine ointments in therapy of experimental herpes simplex virus keratitis in rabbits. The results of the acycloguanosine group were significantly better than the control groups and both other treatment groups, while producing none of the toxic side effects of increasing iritis, conjunctivitis or stromal keratitis, with continued drug application.

摘要

在一项双盲对照研究中，我们比较了3%的阿昔洛韦、0.5%的碘苷和3%的阿糖腺苷眼膏对兔实验性单纯疱疹病毒性角膜炎的治疗效果。阿昔洛韦组的治疗效果明显优于对照组和其他两个治疗组，且持续用药时不会产生虹膜炎、结膜炎或基质性角膜炎加重等毒副作用。