Cortelezzi A, Cattaneo C, Cristiani S, Duca L, Sarina B, Deliliers G L, Fiorelli G, Cappellini M D
Servizio Autonomo di Ematologia Diagnostica, Ospedale Maggiore, IRCCS, Milano, Italy.
Hematol J. 2000;1(3):153-8. doi: 10.1038/sj.thj.6200028.
Iron overload is usually observed in patients (even untransfused) with myelodysplastic syndromes (MDS), and contributes towards the generation of low molecular weight iron complexes or non-transferrin-bound iron (NTBI), which in turn favors oxidative DNA damage and consequent apoptosis.
Levels of NTBI and lipid peroxidation were evaluated by means of free serum malondyaldehyde (MDA) in untransfused MDS patients and we tried to correlate them with ineffective erythropoiesis, apoptosis and the pattern of in vitro growth.
NTBI levels were found to be significantly higher in low-risk than in high-risk MDS patients, as well as in patients with a lower myeloid/erythroid ratio. MDA was found to be uniformly higher in the MDS patients as a whole than in normal controls. The bone marrow progenitor cells in the MDS patients with high NTBI levels showed a higher degree of apoptosis, but this difference was not statistically significant. Patients with a leukemic growth pattern had lower NTBI levels than those with a non-leukemic pattern.
These data suggest that NTBI is related to the degree of ineffective erythropoiesis and that it contributes towards inducing apoptosis in MDS bone marrow precursors. The presence of leukemic growth is associated with low NTBI levels, probably due to increased iron consumption by blast cells.
铁过载通常在骨髓增生异常综合征（MDS）患者（甚至未输血者）中观察到，并且有助于低分子量铁复合物或非转铁蛋白结合铁（NTBI）的产生，这反过来又有利于氧化性DNA损伤及随之而来的细胞凋亡。
通过游离血清丙二醛（MDA）评估未输血MDS患者的NTBI水平和脂质过氧化情况，并试图将它们与无效红细胞生成、细胞凋亡及体外生长模式相关联。
发现低危MDS患者的NTBI水平显著高于高危患者，以及骨髓/红细胞比例较低的患者。发现MDS患者总体的MDA水平均高于正常对照。NTBI水平高的MDS患者的骨髓祖细胞显示出更高程度的细胞凋亡，但这种差异无统计学意义。白血病生长模式的患者NTBI水平低于非白血病模式的患者。
这些数据表明NTBI与无效红细胞生成的程度相关，并且它有助于诱导MDS骨髓前体细胞的凋亡。白血病生长的存在与低NTBI水平相关，可能是由于原始细胞铁消耗增加所致。
