Rodríguez-García Alba, García-Vicente Roberto, Morales María Luz, Ortiz-Ruiz Alejandra, Martínez-López Joaquín, Linares María
Department of Translational Hematology, Instituto de Investigación Hospital 12 de Octubre (i+12), Hematological Malignancies Clinical Research Unit H120-CNIO, CIBERONC, ES 28041 Madrid, Spain.
Department of Medicine, Medicine School, Universidad Complutense de Madrid, ES 28040 Madrid, Spain.
Antioxidants (Basel). 2020 Dec 1;9(12):1212. doi: 10.3390/antiox9121212.
Among the different mechanisms involved in oxidative stress, protein carbonylation and lipid peroxidation are both important modifications associated with the pathogenesis of several diseases, including cancer. Hematopoietic cells are particularly vulnerable to oxidative damage, as the excessive production of reactive oxygen species and associated lipid peroxidation suppress self-renewal and induce DNA damage and genomic instability, which can trigger malignancy. A richer understanding of the clinical effects of oxidative stress might improve the prognosis of these diseases and inform therapeutic strategies. The most common protein carbonylation and lipid peroxidation compounds, including hydroxynonenal, malondialdehyde, and advanced oxidation protein products, have been investigated for their potential effect on hematopoietic cells in several studies. In this review, we focus on the most important protein carbonylation and lipid peroxidation biomarkers in hematological malignancies, their role in disease development, and potential treatment implications.
在氧化应激涉及的不同机制中，蛋白质羰基化和脂质过氧化都是与包括癌症在内的多种疾病发病机制相关的重要修饰。造血细胞特别容易受到氧化损伤，因为活性氧的过量产生及相关的脂质过氧化会抑制自我更新，并诱导DNA损伤和基因组不稳定，进而引发恶性肿瘤。对氧化应激临床效应的更深入了解可能会改善这些疾病的预后并为治疗策略提供依据。在多项研究中，已经对包括羟基壬烯醛、丙二醛和晚期氧化蛋白产物在内的最常见蛋白质羰基化和脂质过氧化化合物对造血细胞的潜在影响进行了研究。在本综述中，我们重点关注血液系统恶性肿瘤中最重要的蛋白质羰基化和脂质过氧化生物标志物、它们在疾病发展中的作用以及潜在的治疗意义。
