Johnstone Peter A S, Niemtzow Richard C, Riffenburgh Robert H
Radiation Oncology Service, Naval Medical Center, San Diego, California 92134-1014, USA.
Cancer. 2002 Feb 15;94(4):1151-6.
In the authors' clinic, patients with xerostomia after radiation therapy for malignancy have been offered acupuncture as potential palliation of their symptoms since November 1999. Preliminary data revealed that many patients achieve relief, even for symptoms refractory to pilocarpine therapy.
Acupuncture technique has been refined since the authors' previous publication. Originally described as a two-step process, a single treatment with eight needles is now used. Three points are treated in each ear, and one in the radial aspect of each index finger. Patients are also provided a sugar-free lozenge in the mouth to further stimulate salivation. Response is measured by the xerostomia inventory (XI).
Fifty patients have undergone 318 treatments (median, 5; range, 2-15 treatments). Median follow-up since the first treatment is 224 days (range, 9-455 days). Median palliation as described by the XI was 9 points (range, 0-25 points). Response (defined as improvement of 10% or better over baseline XI values) occurred in 35 patients (70%). Twenty-four patients (48%) have received benefit of 10 points or greater on the XI. Duration of effect for 13 patients (26%) has exceeded 3 months.
Acupuncture palliates xerostomia for many patients. A regimen of three to four weekly treatments followed by monthly sessions is now recommended, although some patients achieve lasting response without further therapy.
自1999年11月起,在作者所在的诊所,对于恶性肿瘤放疗后出现口干症的患者,已采用针刺疗法来缓解其症状。初步数据显示,许多患者的症状得到缓解,即使是对毛果芸香碱治疗无效的症状。
自作者上次发表文章以来,针刺技术已得到改进。最初描述为两步法,现在采用一次使用八根针的单一治疗方法。每只耳朵治疗三个穴位,每只食指桡侧治疗一个穴位。还会给患者口中含一片无糖含片以进一步刺激唾液分泌。通过口干症量表(XI)来衡量反应。
50名患者接受了318次治疗(中位数为5次;范围为2 - 15次治疗)。自首次治疗后的中位随访时间为224天(范围为9 - 455天)。XI所描述的中位缓解程度为9分(范围为0 - 25分)。35名患者(70%)出现反应(定义为比基线XI值改善10%或更多)。24名患者(48%)在XI上获得了10分或更高的改善。13名患者(26%)的疗效持续时间超过了3个月。
针刺疗法可缓解许多患者的口干症。现在推荐每周进行三到四次治疗,随后每月进行一次治疗的方案,不过一些患者无需进一步治疗就能获得持久反应。