Dosoo D K, Rana S V, Offe-Amoyaw K, Tete-Donkor D, Maddy S Q
Department of Chemical Pathology, University of Ghana Medical School, Accra, Ghana.
West Afr J Med. 2001 Jul-Sep;20(3):184-6.
Total antioxidant status (TAS) was measured in thirty-five (35) non-insulin-dependent diabetes mellitus (NIDDM) patients aged 40 to 65 (mean +/- SE 49.6 +/- 1.0) years. Patients were on diet and oral hypoglycaemic drug (Daonil) therapy with fasting plasma glucose (FPG) >7.8mmol/l. Similar measurements were carried out in thirty-four apparently healthy individuals within the same age range (mean + SE 46.3 +/- 1.1 years) and FPG <6.4 mmol/L. FPG was measured by glucose oxidase method and TAS by colorimetric method. Comparing the two groups, TAS was significantly reduced in the NIDDM patients (p<0.001). An inverse correlation between FPG and TAS suggests the existence of lower antioxidant defence in uncontrolled NIDDM. A good control of FPG accompanied with antioxidant therapy could help reduce free radical activity and minimise complications associated with increased free radical activity in diabetic patients.
对35名年龄在40至65岁（平均±标准误 49.6±1.0岁）的非胰岛素依赖型糖尿病（NIDDM）患者测定了总抗氧化状态（TAS）。这些患者采用饮食和口服降糖药（达美康）治疗，空腹血糖（FPG）>7.8mmol/l。对34名年龄范围相同（平均+标准误 46.3±1.1岁）且FPG<6.4 mmol/L的明显健康个体进行了类似测量。FPG采用葡萄糖氧化酶法测定，TAS采用比色法测定。比较两组发现，NIDDM患者的TAS显著降低（p<0.001）。FPG与TAS之间的负相关表明，未得到控制的NIDDM患者存在较低的抗氧化防御能力。良好地控制FPG并辅以抗氧化治疗有助于降低自由基活性，并将糖尿病患者因自由基活性增加而引发的并发症降至最低。
