Akinosun O M, Bolajoko E B
Department of Chemical Pathology, University College Hospital Ibadan, Nigeria.
Niger J Clin Pract. 2007 Jun;10(2):126-9.
Total antioxidant status (TAS) was measured in 20 Type 2 diabetic patients aged 40-60 years (mean 50 years). Patients were on diet and oral hypoglycemic drug therapy, with fasting plasma glucose (FPG) levels > 7.0 mmol/L. Similar measurements were carried out in 20 apparently healthy individuals within the same age range (mean 46 years) and with FPG levels < 6.1 mmol/L. FPG was measured by glucose oxidase method and TAS by a colourimetric method. Comparing the two groups, TAS was significantly reduced in the Type 2 diabetic patients (0.96 +/- 0.37 Vs 1.61 +/- 0.16 mmol/L) (P < 0.05). An inverse correlation between FPG and TAS suggested the existence of a lower antioxidant defense in poorly controlled Type 2 diabetics. Good control of FPG, could possibly help reduce free radical activity and probably minimize the chronic complications in diabetic patients.
对20名年龄在40至60岁（平均50岁）的2型糖尿病患者进行了总抗氧化状态（TAS）测定。这些患者采用饮食和口服降糖药物治疗，空腹血糖（FPG）水平>7.0 mmol/L。对20名年龄范围相同（平均46岁）且FPG水平<6.1 mmol/L的明显健康个体进行了类似测量。FPG采用葡萄糖氧化酶法测量，TAS采用比色法测量。比较两组发现，2型糖尿病患者的TAS显著降低（0.96±0.37对1.61±0.16 mmol/L）（P<0.05）。FPG与TAS之间存在负相关，表明血糖控制不佳的2型糖尿病患者抗氧化防御能力较低。良好控制FPG可能有助于降低自由基活性，并可能将糖尿病患者的慢性并发症降至最低。
