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Tuning rate of the bergman cyclization of benzannelated enediynes with ortho substituents.

作者信息

Alabugin Igor V, Manoharan Mariappan, Kovalenko Serguei V

机构信息

Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306-4390, USA.

出版信息

Org Lett. 2002 Apr 4;4(7):1119-22. doi: 10.1021/ol0255054.

DOI:10.1021/ol0255054
PMID:11922797
Abstract

[reaction: see text] The Bergman cyclization of benzannelated enediynes is highly sensitive to ortho substitution. This finding opens possibilities for the rational design of conformer-specific and pH-dependent DNA-cleaving agents.

摘要

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