Differential expression of Otx2, Gbx2, Pax2, and Fgf8 in the developing vestibular and auditory sensory organs.

The vertebrate inner ear is a complex organ with vestibular and auditory sensory functions, which derives from a single ectoderm structure, the otic placode. The development and regional patterning of the otic primordium is determined by the restricted expression of several genes. Here, we show the expression pattern of three transcription factors (Otx2, Gbx2, Pax2) and of a member of the fibroblast growth factor family (Fgf8) in the developing chick inner ear, and we correlate these patterns with the developing sensory and nonsensory elements.