Sánchez-Calderón Hortensia, Martín-Partido Gervasio, Hidalgo-Sánchez Matías
Departamento de Biología Celular, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain.
Brain Res Bull. 2002;57(3-4):321-3. doi: 10.1016/s0361-9230(01)00725-0.
The vertebrate inner ear is a complex organ with vestibular and auditory sensory functions, which derives from a single ectoderm structure, the otic placode. The development and regional patterning of the otic primordium is determined by the restricted expression of several genes. Here, we show the expression pattern of three transcription factors (Otx2, Gbx2, Pax2) and of a member of the fibroblast growth factor family (Fgf8) in the developing chick inner ear, and we correlate these patterns with the developing sensory and nonsensory elements.
脊椎动物的内耳是一个具有前庭和听觉感觉功能的复杂器官，它起源于单一的外胚层结构——耳基板。耳原基的发育和区域模式是由几个基因的限制性表达决定的。在这里，我们展示了三种转录因子（Otx2、Gbx2、Pax2）和成纤维细胞生长因子家族成员（Fgf8）在发育中的鸡内耳中的表达模式，并将这些模式与发育中的感觉和非感觉元件相关联。
