Ikeda Masataka, Furukawa Hiroshi, Imamura Hiroshi, Shimizu Jyunzo, Ishida Hideyuki, Masutani Seizo, Tatsuta Masayuki, Satomi Takashi
Department of Surgery, Sakai Municipal Hospital, Sakai, Japan.
Ann Surg Oncol. 2002 Apr;9(3):287-91. doi: 10.1007/BF02573067.
Thrombocytosis is commonly associated with malignant disease and has recently been suggested to be a poor prognostic indicator in patients with lung cancer and gynecological cancers. The prevalence of thrombocytosis in patients with gastric cancer was reviewed, and its association with poor prognosis was investigated.
Platelet count (PLT) and hemoglobin concentrations (Hb) were reviewed in 369 consecutive patients with histologically verified gastric cancer from 1994 to 2000. Differences between categories were analyzed with analysis of variance, and survival was compared by using the log-rank test on the Kaplan-Meier life table. Multivariate Cox regression analysis was used to evaluate whether thrombocytosis is an independent prognostic marker.
Thrombocytosis was found in 42 patients, and anemia was found in 200 patients. PLT was negatively correlated with Hb. Mean PLT was significantly increased in patients with noncurative operations. There was a positive correlation between the depth of tumor invasion and PLT. One- and 3-year survival expectancies in patients with or without thrombocytosis were 52.4% and 23.4% and 85.7% and 72.9%, respectively. PLT was identified as an independent prognostic factor after lymph node metastasis and depth of tumor invasion.
Thrombocytosis is an independent prognostic indicator of survival in patients with gastric cancer.
血小板增多症通常与恶性疾病相关，最近有研究表明它是肺癌和妇科癌症患者预后不良的指标。本研究回顾了胃癌患者中血小板增多症的患病率，并调查了其与预后不良的关系。
回顾了1994年至2000年间369例经组织学证实的胃癌患者的血小板计数（PLT）和血红蛋白浓度（Hb）。采用方差分析分析组间差异，并使用Kaplan-Meier生存表上的对数秩检验比较生存率。多因素Cox回归分析用于评估血小板增多症是否为独立的预后标志物。
42例患者发现血小板增多症，200例患者发现贫血。PLT与Hb呈负相关。非根治性手术患者的平均PLT显著升高。肿瘤浸润深度与PLT呈正相关。有或无血小板增多症患者的1年和3年生存率分别为52.4%和23.4%以及85.7%和72.9%。在淋巴结转移和肿瘤浸润深度之后，PLT被确定为独立的预后因素。
血小板增多症是胃癌患者生存的独立预后指标。
