DeWys W D, Walters K
Cancer. 1975 Nov;36(5):1888-96. doi: 10.1002/1097-0142(197511)36:5<1888::aid-cncr2820360546>3.0.co;2-y.
In fifty patients with cancer, subjective and objective correlates of anorexia of malignancy were studied. Decreased taste was reported by 25 patients, and an aversion for meat was reported by 16 patients. The decreased taste symptom correlated with an elevated taste threshold for sweet (sucrose), and the symptom of meat aversion correlated with a lowered taste threshold for bitter (urea). The likelihood of having a taste abnormality increased with increasing extent of disease, but not with histologic type of neoplasm. Patients with an abnormality of taste had an increased incidence of weight loss compared with patients with normal taste, even though many in the latter group had other causes of weight loss. These observations suggest that an abnormality of taste may be one determinant of the anorexia of malignancy. Better understanding of the anorexia in the cancer patient may contribute to the care of the patient.
对50例癌症患者的恶性肿瘤所致厌食的主观和客观相关因素进行了研究。25例患者报告味觉减退，16例患者报告厌恶肉类。味觉减退症状与甜味（蔗糖）味觉阈值升高相关，厌恶肉类症状与苦味（尿素）味觉阈值降低相关。味觉异常的可能性随疾病程度的增加而增加，但与肿瘤的组织学类型无关。与味觉正常的患者相比，味觉异常的患者体重减轻的发生率更高，尽管后一组中的许多患者有其他导致体重减轻的原因。这些观察结果表明，味觉异常可能是恶性肿瘤所致厌食的一个决定因素。更好地了解癌症患者的厌食情况可能有助于对患者的护理。
