Larsson L G, Sandström A, Westling P
Cancer Res. 1975 Nov;35(11 Pt. 2):3308-16.
Sideropenic anemia with epithelial lesions (Plummer-Vinson syndrome) was previously very common among women in northern Sweden. The incidence of this condition is decreasing, however, because of better nutrition and improved health care. Plummer-Vinson syndrome as a sequela of previous sideropenic anemia still influences the pattern of hypopharyngeal and oral cancer in northern Sweden where the female/male ratio in these diseases is remarkably high and where cancer in the postcricoid part of the hypopharynx is relatively common. In Sweden as a whole, a decreasing trend in the incidence of hypopharyngeal cancer in women can be demonstrated, which is probably due to diminished prevalence of Plummer-Vinson syndrome.
伴有上皮病变的缺铁性贫血（普拉默-文森综合征）曾在瑞典北部女性中极为常见。然而，由于营养状况改善和医疗保健水平提高，这种病症的发病率正在下降。普拉默-文森综合征作为既往缺铁性贫血的后遗症，仍影响着瑞典北部下咽癌和口腔癌的发病模式，在这些疾病中，女性与男性的比例显著偏高，且下咽环状软骨后部分的癌症相对常见。在瑞典全国范围内，可以证明女性下咽癌发病率呈下降趋势，这可能是由于普拉默-文森综合征的患病率降低所致。
