Nicholson Martha, King Jaimee, Smith Paul F, Darlington Cynthia L
Department of Psychology and the Neuroscience Research Centre, University of Otago, Dunedin, New Zealand.
Neuroreport. 2002 Jan 21;13(1):153-7. doi: 10.1097/00001756-200201210-00035.
We compared vestibulo-ocular reflex, optokinetic reflex and postural function in subjects with insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM), as well as non-diabetic controls. Both IDDM and NIDDM subjects exhibited significant deficits in gaze-holding in darkness (p < 0.05), small changes in vestibulo-ocular reflex (VOR) phase re velocity (p < 0.005) without a change in VOR gain, and a decrease in optokinetic reflex (OKR) slow phase velocity (p < 0.001). In addition, a smaller decrease was found in OKR quick phase amplitude (p < 0.02); postural sway was increased in both diabetic groups (p < 0.05), although this was not specific to the conditions of the Clinical Test of Sensory Interaction and Balance (CTSIB) that test vestibular contributions to postural stability. No differences were found in optokinetic afternystagmus or latency to circularvection. These results suggest that both IDDM and NIDDM are associated with deficits in gaze-holding, VOR and OKR function.
我们比较了胰岛素依赖型糖尿病（IDDM）患者、非胰岛素依赖型糖尿病（NIDDM）患者以及非糖尿病对照组的前庭眼反射、视动反射和姿势功能。IDDM和NIDDM患者在黑暗中凝视稳定性方面均表现出显著缺陷（p < 0.05），前庭眼反射（VOR）相速度有微小变化（p < 0.005），而VOR增益无变化，视动反射（OKR）慢相速度降低（p < 0.001）。此外，OKR快相幅度下降幅度较小（p < 0.02）；两个糖尿病组的姿势摆动均增加（p < 0.05），尽管这并非特定于测试前庭对姿势稳定性贡献的感觉交互和平衡临床测试（CTSIB）的条件。在视动性眼震后效或旋转性眼动潜伏期方面未发现差异。这些结果表明，IDDM和NIDDM均与凝视稳定性、VOR和OKR功能缺陷有关。
