• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Spatial frequency threshold and contrast sensitivity of an optomotor behavior are impaired in the Ins2Akita mouse model of diabetes.糖尿病 Ins2Akita 小鼠模型的光感受器运动行为的空间频率阈值和对比敏感度受损。
Behav Brain Res. 2012 Jan 15;226(2):601-5. doi: 10.1016/j.bbr.2011.09.030. Epub 2011 Sep 28.
2
Reduced ocular blood flow as an early indicator of diabetic retinopathy in a mouse model of diabetes.糖尿病模型小鼠中眼血流减少可作为糖尿病性视网膜病变的早期指标。
Invest Ophthalmol Vis Sci. 2012 Sep 21;53(10):6488-94. doi: 10.1167/iovs.12-9758.
3
Absence of clinical correlates of diabetic retinopathy in the Ins2Akita retina.在 Ins2Akita 视网膜中，糖尿病性视网膜病变的临床相关性缺失。
Clin Exp Ophthalmol. 2013 Aug;41(6):582-92. doi: 10.1111/ceo.12084. Epub 2013 May 21.
4
Loss of scotopic contrast sensitivity in the optomotor response of diabetic mice.糖尿病小鼠光运动反应中暗视对比敏感度的丧失。
Invest Ophthalmol Vis Sci. 2013 Feb 28;54(2):1536-43. doi: 10.1167/iovs.12-10825.
5
The Ins2Akita mouse as a model of early retinal complications in diabetes.Ins2Akita小鼠作为糖尿病早期视网膜并发症的模型。
Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2210-8. doi: 10.1167/iovs.04-1340.
6
Loss-of-function mutation of serine racemase attenuates retinal ganglion cell loss in diabetic mice.丝氨酸消旋酶功能丧失突变可减轻糖尿病小鼠的视网膜神经节细胞丢失。
Exp Eye Res. 2018 Oct;175:90-97. doi: 10.1016/j.exer.2018.06.017. Epub 2018 Jun 18.
7
Retinal angiogenesis in the Ins2(Akita) mouse model of diabetic retinopathy.糖尿病视网膜病变 Ins2(Akita)小鼠模型中的视网膜血管生成。
Invest Ophthalmol Vis Sci. 2013 Jan 17;54(1):574-84. doi: 10.1167/iovs.12-10959.
8
A mitochondrial therapeutic reverses visual decline in mouse models of diabetes.一种线粒体疗法可逆转糖尿病小鼠模型的视力下降。
Dis Model Mech. 2015 Jul 1;8(7):701-10. doi: 10.1242/dmm.020248. Epub 2015 Apr 23.
9
Diabetic myopathy differs between Ins2Akita+/- and streptozotocin-induced Type 1 diabetic models.糖尿病性肌病在Ins2Akita+/-小鼠模型和链脲佐菌素诱导的1型糖尿病模型中存在差异。
J Appl Physiol (1985). 2009 May;106(5):1650-9. doi: 10.1152/japplphysiol.91565.2008. Epub 2009 Feb 26.
10
Dysregulation of trophic factors contributes to diabetic retinopathy in the Ins2 mouse.营养因子失调导致 Ins2 小鼠发生糖尿病性视网膜病变。
Exp Eye Res. 2020 May;194:108027. doi: 10.1016/j.exer.2020.108027. Epub 2020 Apr 4.

引用本文的文献

1
SMOX Inhibition Preserved Visual Acuity, Contrast Sensitivity, and Retinal Function and Reduced Neuro-Glial Injury in Mice During Prolonged Diabetes.在长期糖尿病小鼠中，SMOX抑制可保留视力、对比敏感度和视网膜功能，并减少神经胶质损伤。
Cells. 2024 Dec 12;13(24):2049. doi: 10.3390/cells13242049.
2
Correlation of Retinal Structure and Visual Function Assessments in Mouse Diabetes Models.鼠糖尿病模型中视网膜结构与视觉功能评估的相关性。
Invest Ophthalmol Vis Sci. 2021 Aug 2;62(10):20. doi: 10.1167/iovs.62.10.20.
3
Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes.血管表达渗透性抗性闭合蛋白突变体可维持糖尿病患者的视觉功能。
Diabetes. 2021 Jul;70(7):1549-1560. doi: 10.2337/db20-1220. Epub 2021 Apr 21.
4
Diabetic photoreceptors: Mechanisms underlying changes in structure and function.糖尿病患者的感光细胞：结构和功能变化的机制。
Vis Neurosci. 2020 Oct 6;37:E008. doi: 10.1017/S0952523820000097.
5
Dopamine metabolite levels in the vitreous of diabetic and non-diabetic humans.糖尿病患者和非糖尿病患者玻璃体液中的多巴胺代谢产物水平。
Exp Eye Res. 2020 Jun;195:108040. doi: 10.1016/j.exer.2020.108040. Epub 2020 Apr 29.
6
Novel Detection and Restorative Levodopa Treatment for Preclinical Diabetic Retinopathy.新型检测技术与修复性左旋多巴治疗糖尿病视网膜病变的临床前期研究。
Diabetes. 2020 Jul;69(7):1518-1527. doi: 10.2337/db19-0869. Epub 2020 Feb 12.
7
Role of Arginase 2 in Murine Retinopathy Associated with Western Diet-Induced Obesity.精氨酸酶2在与西方饮食诱导的肥胖相关的小鼠视网膜病变中的作用
J Clin Med. 2020 Jan 22;9(2):317. doi: 10.3390/jcm9020317.
8
Visual Behavior Impairments as an Aberrant Sensory Processing in the Mouse Model of Fragile X Syndrome.视觉行为障碍作为脆性X综合征小鼠模型中的一种异常感觉处理
Front Behav Neurosci. 2019 Oct 2;13:228. doi: 10.3389/fnbeh.2019.00228. eCollection 2019.
9
Visual Contrast Sensitivity Correlates to the Retinal Degeneration in Rhodopsin Knockout Mice.视觉对比敏感度与视紫红质敲除小鼠的视网膜变性相关。
Invest Ophthalmol Vis Sci. 2019 Oct 1;60(13):4196-4204. doi: 10.1167/iovs.19-26966.
10
Loss of XBP1 Leads to Early-Onset Retinal Neurodegeneration in a Mouse Model of Type I Diabetes.XBP1缺失导致I型糖尿病小鼠模型中早发性视网膜神经退行性变。
J Clin Med. 2019 Jun 25;8(6):906. doi: 10.3390/jcm8060906.

本文引用的文献

1
An integrated approach to diabetic retinopathy research.糖尿病视网膜病变研究的综合方法。
Arch Ophthalmol. 2011 Feb;129(2):230-5. doi: 10.1001/archophthalmol.2010.362.
2
Validation of structural and functional lesions of diabetic retinopathy in mice.小鼠糖尿病视网膜病变结构和功能损伤的验证
Mol Vis. 2010 Oct 19;16:2121-31.
3
Age-related deterioration of rod vision in mice.小鼠的杆状视觉与年龄相关的退化。
J Neurosci. 2010 Aug 18;30(33):11222-31. doi: 10.1523/JNEUROSCI.4239-09.2010.
4
Visual dysfunction associated with diabetic retinopathy.与糖尿病视网膜病变相关的视觉功能障碍。
Curr Diab Rep. 2010 Oct;10(5):380-4. doi: 10.1007/s11892-010-0132-4.
5
Global transcriptional programs in peripheral nerve endoneurium and DRG are resistant to the onset of type 1 diabetic neuropathy in Ins2 mice.周围神经内膜和背根神经节中的全球转录程序对 1 型糖尿病神经病变在 Ins2 小鼠中的发生具有抗性。
PLoS One. 2010 May 26;5(5):e10832. doi: 10.1371/journal.pone.0010832.
6
Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice.缓激肽B1和B2受体均缺失会加重秋田糖尿病小鼠的肾病、神经病变和骨矿物质流失。
Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10190-5. doi: 10.1073/pnas.1005144107. Epub 2010 May 17.
7
Initiation of the optokinetic response (OKR) in mice.小鼠视动反应（OKR）的启动。
J Vis. 2010 Jan 29;10(1):13.1-17. doi: 10.1167/10.1.13.
8
Neuritic dystrophy and neuronopathy in Akita (Ins2(Akita)) diabetic mouse sympathetic ganglia.阿基塔（Ins2(Akita)）糖尿病小鼠交感神经节中的神经炎性营养不良和神经元病。
Exp Neurol. 2009 Mar;216(1):207-18. doi: 10.1016/j.expneurol.2008.11.019. Epub 2008 Dec 10.
9
Regulation of pancreatic beta cell mass by neuronal signals from the liver.肝脏神经元信号对胰腺β细胞质量的调节。
Science. 2008 Nov 21;322(5905):1250-4. doi: 10.1126/science.1163971.
10
The role of Humphrey Matrix testing in the early diagnosis of retinopathy in type 1 diabetes.汉弗莱矩阵测试在1型糖尿病视网膜病变早期诊断中的作用。
Br J Ophthalmol. 2008 Dec;92(12):1656-60. doi: 10.1136/bjo.2008.143057. Epub 2008 Oct 1.

糖尿病 Ins2Akita 小鼠模型的光感受器运动行为的空间频率阈值和对比敏感度受损。

Spatial frequency threshold and contrast sensitivity of an optomotor behavior are impaired in the Ins2Akita mouse model of diabetes.

机构信息

Department of Physiology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, United States.

出版信息

Behav Brain Res. 2012 Jan 15;226(2):601-5. doi: 10.1016/j.bbr.2011.09.030. Epub 2011 Sep 28.

DOI:10.1016/j.bbr.2011.09.030
PMID:21963766
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3298119/
Abstract

Diabetic retinopathy can lead to progressive loss of vision and is a leading cause of blindness. The Ins2(Akita) mouse model of diabetes develops significant retinal and systemic pathology, but how these affect visual behavior is unknown. Here, we show that Ins2(Akita) mice have progressive, quantifiable vision deficits in an optomotor behavior. This mouse line is a promising model in which to understand the contribution of retinal neuronal injury during the chronic hyperglycemia and hypoinsulinemia of diabetes to deficits in vision.

摘要

糖尿病视网膜病变可导致视力逐渐丧失，是失明的主要原因。Ins2(Akita) 糖尿病小鼠模型会出现显著的视网膜和全身病理变化，但这些变化如何影响视觉行为尚不清楚。在这里，我们展示了 Ins2(Akita) 小鼠在光感受器行为中存在进行性、可量化的视觉缺陷。该小鼠品系是一个很有前途的模型，可以了解在糖尿病的慢性高血糖和胰岛素缺乏期间视网膜神经元损伤对视功能缺陷的贡献。