糖尿病 Ins2Akita 小鼠模型的光感受器运动行为的空间频率阈值和对比敏感度受损。
Spatial frequency threshold and contrast sensitivity of an optomotor behavior are impaired in the Ins2Akita mouse model of diabetes.
机构信息
Department of Physiology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, United States.
出版信息
Behav Brain Res. 2012 Jan 15;226(2):601-5. doi: 10.1016/j.bbr.2011.09.030. Epub 2011 Sep 28.
Abstract
Diabetic retinopathy can lead to progressive loss of vision and is a leading cause of blindness. The Ins2(Akita) mouse model of diabetes develops significant retinal and systemic pathology, but how these affect visual behavior is unknown. Here, we show that Ins2(Akita) mice have progressive, quantifiable vision deficits in an optomotor behavior. This mouse line is a promising model in which to understand the contribution of retinal neuronal injury during the chronic hyperglycemia and hypoinsulinemia of diabetes to deficits in vision.
摘要
糖尿病视网膜病变可导致视力逐渐丧失，是失明的主要原因。Ins2(Akita) 糖尿病小鼠模型会出现显著的视网膜和全身病理变化，但这些变化如何影响视觉行为尚不清楚。在这里，我们展示了 Ins2(Akita) 小鼠在光感受器行为中存在进行性、可量化的视觉缺陷。该小鼠品系是一个很有前途的模型，可以了解在糖尿病的慢性高血糖和胰岛素缺乏期间视网膜神经元损伤对视功能缺陷的贡献。
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