Lindstedt S, Steen G
Clin Chem. 1975 Dec;21(13):1964-9.
An acetylenic dicarboxylic acid, 5-decynedioic acid, has been isolated from human urine. The structure was determined by mass spectrometry of several derivatives, and by infrared spectroscopy. On osmium tetroxide oxidation, a vic-diketone was formed, the mass spectrum of which established the position of the triple bond between carbon atoms 5 and 6. Mass spectrometric evidence for the presence of a small amount of the isomeric 4-decynedioic acid was also obtained. The 24-h excretion of these acids is 0.01-0.1 mmol for healthy adults on a regular diet.
一种炔二羧酸，即5-癸炔二酸，已从人尿中分离出来。其结构通过几种衍生物的质谱分析和红外光谱确定。经四氧化锇氧化后，形成了一种邻二酮，其质谱确定了三键在碳原子5和6之间的位置。还获得了存在少量异构体4-癸炔二酸的质谱证据。对于饮食规律的健康成年人，这些酸的24小时排泄量为0.01 - 0.1毫摩尔。
