Thurmond J B, Lasley S M, Kramarcy N R, Brown J W
Psychopharmacology (Berl). 1979;66(3):301-8. doi: 10.1007/BF00428324.
Male albino mice were maintained on a semisynthetic 12% casein protein diet for 2 weeks, then switched to diets modified by the addition of a 4% L-amino acid supplement (L-tyrosine, L-phenylalanine, and L-tryptophan) or 4% casein (control). Territorial=induced aggressive behavior increased following 1 week on the amino acid supplements, especially after tyrosine, but an apparent tolerance developed to these effects after 5 weeks on the amino acid supplements. Locomotor activity also increased following 1 week on the supplements, most notably after phenylalanine alone or in combination with tyrosine, and these effects tended to persist after 5 weeks on the supplements. Endogenous whole brain levels of dopamine, norepinephrine, serotonin, 5-hydroxyindoleacetic acid, tyrosine, phenylalanine, and tryptophan showed no tolerance to increased concentrations of brain catecholamines and indoleamines over the 5-week period, and no clear relation between the concentrations of these monoamines and the behavioral changes.
雄性白化小鼠先在含12%酪蛋白的半合成蛋白质饮食中饲养2周，然后换成添加4% L - 氨基酸补充剂（L - 酪氨酸、L - 苯丙氨酸和L - 色氨酸）或4%酪蛋白（对照）的改良饮食。在补充氨基酸1周后，领地诱导的攻击行为增加，尤其是在补充酪氨酸后，但在补充氨基酸5周后，对这些影响出现了明显的耐受性。补充剂喂养1周后，运动活动也增加，最明显的是单独补充苯丙氨酸或与酪氨酸联合补充后，且在补充剂喂养5周后这些影响仍倾向于持续存在。在5周的时间里，内源性全脑多巴胺、去甲肾上腺素、血清素、5 - 羟吲哚乙酸、酪氨酸、苯丙氨酸和色氨酸的水平对脑儿茶酚胺和吲哚胺浓度的增加没有耐受性，且这些单胺的浓度与行为变化之间没有明显关系。
