Westermark P, Johansson B, Natvig J B
Scand J Immunol. 1979;10(4):303-8. doi: 10.1111/j.1365-3083.1979.tb01355.x.
In a material of seventy-two persons over 70 years of age, forty-seven cases of amyloidosis of the heart were found. In thirty-nine cases, deposits occurred only in the atria (isolated artrial amyloidosis, IAA), while in eight cases amyloid also was seen in the ventricles (senile cardiac amyloidosis, SCA). In some of the latter cases, small amyloid deposits occurred in other organs, especially the lungs. Some definite differences existed between the amyloid substance in SCA and IAA. Thus, tryptophan was demonstrated histochemically in SCA but not in IAA, and, furthermore, amyloid fibrils isolated from patients with IAA lacked protein Asca, the fibril subunit protein of senile cardiac amyloid. It is concluded that the ageing heart may be the target of two different forms of amyloid, one only affecting the atria, while the other is more widespread within the heart and sometimes also is found in other organs.
在72名70岁以上的人群中，发现了47例心脏淀粉样变性病例。其中39例仅在心房出现沉积物（孤立性心房淀粉样变性，IAA），而在8例中，心室也可见淀粉样物质（老年性心脏淀粉样变性，SCA）。在后者的一些病例中，其他器官尤其是肺部出现了小的淀粉样沉积物。SCA和IAA中的淀粉样物质存在一些明确的差异。因此，组织化学显示SCA中有色氨酸，而IAA中没有，此外，从IAA患者分离出的淀粉样纤维缺乏蛋白质Asca，即老年性心脏淀粉样变性的纤维亚基蛋白。结论是，衰老的心脏可能是两种不同形式淀粉样物质的靶器官，一种仅影响心房，而另一种在心脏内分布更广，有时也见于其他器官。
