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同基因肿瘤的细胞毒性前体细胞频率较高。

A high frequency of cytotoxic precursor cells for a syngeneic tumour.

作者信息

Warren H S, Lafferty K J

出版信息

Scand J Immunol. 1979;10(4):349-52. doi: 10.1111/j.1365-3083.1979.tb01362.x.

DOI:10.1111/j.1365-3083.1979.tb01362.x
PMID:119310
Abstract

The average frequency of cytotoxic precursor cells in DBA/2 lymph node cell preparations reactive to the syngeneic tumour P815 has been determined as 1 in 2000. This frequency is similar to the precursor frequency for an allogeneic tumour EL-4. The normal lack of response of DBA/2 lymph node cells to the syngeneic tumour P815 in vitro cannot be attributed to a lack of cytotoxic precursor cells. We conclude that in this tumour-host system non-immunogenicity reflects a defect at the inductive step.

摘要

已确定，在对同基因肿瘤P815产生反应的DBA/2淋巴结细胞制剂中，细胞毒性前体细胞的平均频率为2000分之一。该频率与同种异体肿瘤EL-4的前体频率相似。DBA/2淋巴结细胞在体外对同基因肿瘤P815正常缺乏反应，不能归因于细胞毒性前体细胞的缺乏。我们得出结论，在这个肿瘤-宿主系统中，非免疫原性反映了诱导步骤的缺陷。

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引用本文的文献

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Reduced tumor growth after low-dose irradiation or immunization against blastic suppressor T cells.低剂量照射或针对母细胞性抑制性T细胞免疫后肿瘤生长减缓。
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1809-12. doi: 10.1073/pnas.78.3.1809.

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