肿瘤细胞在体外对同基因和异基因淋巴细胞的刺激作用。
Stimulation of syngeneic and allogeneic lymphoid cells by tumour cells in vitro.
作者信息
Potter M R, Balfour B M
出版信息
Br J Cancer. 1975 Jul;32(1):5-15. doi: 10.1038/bjc.1975.127.
August and Wistar rat lymph node cells were found to respond well to PHA stimulation and in mixed lymphocyte culture, as determined by an increased incorporation of 3H-thymidine. August rat lymph node cells were also stimulated by incubation with irradiated syngeneic tumour cells. Allogeneic Wistar rat lymph node cells produced a larger response to the August tumour cells. The response of syngeneic and allogeneic lymph node cells was reduced by pretreating the tumour cells with a Wistar anti-tumour serum. Pretreating the tumour cells with sera from normal or tumour bearing rats also reduced the response of syngeneic lymph node cells but did not reduce the response of allogeneic lymph node cells.
研究发现，奥古斯特大鼠和Wistar大鼠的淋巴结细胞对PHA刺激反应良好，在混合淋巴细胞培养中，3H-胸腺嘧啶核苷掺入量增加，这表明了这一点。奥古斯特大鼠的淋巴结细胞与经辐照的同基因肿瘤细胞一起孵育时也受到刺激。异基因Wistar大鼠的淋巴结细胞对奥古斯特肿瘤细胞产生了更大的反应。用Wistar抗肿瘤血清预处理肿瘤细胞可降低同基因和异基因淋巴结细胞的反应。用正常大鼠或荷瘤大鼠的血清预处理肿瘤细胞也降低了同基因淋巴结细胞的反应，但未降低异基因淋巴结细胞的反应。
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