环磷酰胺对同基因肿瘤体外细胞毒性反应的影响。
The effects of cyclophosphamide on in vitro cytotoxic responses to a syngeneic tumour.
作者信息
Hancock E J, Kilburn D G
出版信息
Cancer Immunol Immunother. 1982;14(1):54-8. doi: 10.1007/BF00199433.
Abstract
We have studied the effects of treating DBA/2 mice with high doses of cyclophosphamide upon their subsequent ability to generate cytotoxic cells in vitro against syngeneic tumour antigens or alloantigens. High doses of cyclophosphamide (100-200 mg/kg body weight) eliminated the response to both antigens. The addition of normal DBA/2 thymocytes into these cultures restored the response to allogeneic cells but not to tumour cells. The anti-tumour response could be restored by the addition of interleukin 2 to the cultures. Treatment with high doses of cyclophosphamide decreased the number of anti-tumour cytotoxic cell precursors in the spleen, but did not affect the capacity of bulk cultures of spleen cells to produce interleukin 2 when stimulated with the mitogen concanavalin A.
摘要
我们研究了用高剂量环磷酰胺处理DBA/2小鼠后，其随后在体外针对同基因肿瘤抗原或同种异体抗原产生细胞毒性细胞的能力所受到的影响。高剂量的环磷酰胺（100 - 200毫克/千克体重）消除了对两种抗原的反应。向这些培养物中添加正常的DBA/2胸腺细胞可恢复对异基因细胞的反应，但不能恢复对肿瘤细胞的反应。通过向培养物中添加白细胞介素2可恢复抗肿瘤反应。用高剂量环磷酰胺处理会减少脾脏中抗肿瘤细胞毒性细胞前体的数量，但不影响脾细胞大量培养物在用丝裂原刀豆球蛋白A刺激时产生白细胞介素2的能力。
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