Gerber A, Wiprächtiger P, Spichiger U, Lebek G
Schweiz Med Wochenschr. 1979 Dec 8;109(47):1902-3.
Killing curves of Pseudomonas aeruginosa were performed in an in vitro system simulating in-vivo gentamicin kinetics, i.e. decay of the antibiotic concentration with a 2.1 h halflife time. Minimal inhibitory concentrations (MIC) of gentamicin killed 99.999% of the initial Pseudomonas inoculum whereas 99.99% were killed at a continuously falling gentamicin concentration (starting from the MIC level) in the same period of time. Regrowth of persistent germs occurred only after 6 hours in cultures exposed to falling gentamicin concentrations, and after 8 hours in cultures kept at the MIC. Thus, a postulated superiority of gentamicin infusions over intermittent gentamicin therapy could not be demonstrated in vitro. Intervals between bolus injections of gentamicin should probably not be longer than 6 hours.
在模拟体内庆大霉素动力学的体外系统中进行了铜绿假单胞菌的杀菌曲线实验，即抗生素浓度以2.1小时的半衰期衰减。庆大霉素的最低抑菌浓度（MIC）可杀死99.999%的初始铜绿假单胞菌接种物，而在相同时间段内，当庆大霉素浓度持续下降（从MIC水平开始）时，99.99%的细菌被杀死。在暴露于下降的庆大霉素浓度的培养物中，仅在6小时后出现持续细菌的再生长，而在保持在MIC水平的培养物中，8小时后出现再生长。因此，在体外无法证明庆大霉素输注优于间歇性庆大霉素治疗。庆大霉素推注之间的间隔可能不应超过6小时。
