蝴蝶豆中鱼藤酮类化合物的抗炎活性。
Antiinflammatory activity of rotenoids from Clitoria fairchildiana.
作者信息
Pereira da Silva Bernadete, Paz Parente José
机构信息
Núcleo de Pesquisas de Produtos Naturais, Centro de Ciencias da Saúde, Universidade Federal do Rio de Janeiro, 21944-970, PO Box 68045, Brazil.
出版信息
Phytother Res. 2002 Mar;16 Suppl 1:S87-8. doi: 10.1002/ptr.807.
Five structurally related rotenoids were isolated from the roots of Clitoria fairchildiana. The antiinflammatory activity was investigated using a capillary permeability assay. The protective effect was measured as the inhibition in vascular permeability produced by acetic acid in the peritoneal cavity. The results suggest that for maximum activity the maintenance of the B/C ring junction integrity is important. These findings support the traditional use of Clitoria species extracts in the treatment of inflammatory conditions.
从美花蝶豆的根部分离出了五种结构相关的鱼藤酮类化合物。使用毛细血管通透性测定法研究了其抗炎活性。通过测量腹腔中乙酸引起的血管通透性抑制来评估保护作用。结果表明，为了达到最大活性，保持B/C环连接的完整性很重要。这些发现支持了蝶豆属植物提取物在治疗炎症方面的传统用途。
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