Da Silva Antunes Alexandra, Da Silva Bernadete Pereira, Parente José Paz, Valente Ana Paula
Núcleo de Pesquisas de Produtos Naturiais, Laboratório de Química de Plantas Medicinais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, CEP 21944-970 Rio de Janeiro, RJ, Brasil.
Phytother Res. 2003 Feb;17(2):179-82. doi: 10.1002/ptr.1059.
A new steroidal saponin was isolated from the leaves of Sansevieria cylindrica. Its structure was established as (3beta,12beta,15alpha,25S)-26-(beta-D-glucopyranosyloxy)-22-hydroxyfurost-5-en-3-yl 12-O- (6-deoxy-alpha-L-mannopyranosyl)-15-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside. The structural identification was performed using detailed analyses of (1)H and (13)C NMR spectra including 2D NMR spectroscopic techniques (COSY, HETCOR, HMBC and HMQC) and chemical conversions. The steroidal saponin showed no haemolytic effects in the in vitro assays and demonstrated inhibition of the capillary permeability activity.
从圆筒虎尾兰的叶子中分离出一种新的甾体皂苷。其结构确定为(3β,12β,15α,25S)-26-(β-D-吡喃葡萄糖氧基)-22-羟基呋甾-5-烯-3-基 12-O-(6-脱氧-α-L-吡喃甘露糖基)-15-O-(6-脱氧-α-L-吡喃甘露糖基)-β-D-吡喃葡萄糖苷。通过对(1)H 和(13)C NMR 光谱进行详细分析，包括二维 NMR 光谱技术(COSY、HETCOR、HMBC 和 HMQC)以及化学转化来进行结构鉴定。该甾体皂苷在体外试验中未显示溶血作用，并表现出对毛细血管通透性活性的抑制作用。
