利用生物相关介质中的溶解度和溶出度研究预测难溶性弱碱的口服吸收行为。 - Suppr

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超能文献

Forecasting the oral absorption behavior of poorly soluble weak bases using solubility and dissolution studies in biorelevant media.

作者信息

Kostewicz Edmund S, Brauns Ulrich, Becker Robert, Dressman Jennifer B

机构信息

Institut für Pharmazeutische Technologie. J. W. Goethe Universität, Frankfurt am Main, Germany.

出版信息

Pharm Res. 2002 Mar;19(3):345-9. doi: 10.1023/a:1014407421366.

DOI:10.1023/a:1014407421366

PMID:11934243

Abstract

摘要

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本文引用的文献

Forecasting the in vivo performance of four low solubility drugs from their in vitro dissolution data.根据四种低溶解度药物的体外溶出数据预测其体内性能。

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Evaluation of various dissolution media for predicting in vivo performance of class I and II drugs.评估用于预测I类和II类药物体内性能的各种溶出介质。

Pharm Res. 1998 May;15(5):698-705. doi: 10.1023/a:1011910801212.

Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms.作为口服药物吸收预后工具的溶出度测试：速释剂型

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Solubilizing properties of bile salt solutions. I. Effect of temperature and bile salt concentration on solubilization of glutethimide, griseofulvin, and hexestrol.

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Upper gastrointestinal (GI) pH in young, healthy men and women.年轻健康男性和女性的上消化道pH值。

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Influence of food on the bioavailability of drugs.食物对药物生物利用度的影响。

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