与进行性核上性麻痹和阿尔茨海默病相关的铁蛋白核心中铁的结构形式

On the structural form of iron in ferritin cores associated with progressive supranuclear palsy and Alzheimer's disease.

作者信息

Dobson J

机构信息

Centre for Science and Technology in Medicine, Department of Biomedical Engineering and Medical Physics, Keele University, Hartshill, Stoke-on-Trent, UK.

出版信息

Cell Mol Biol (Noisy-le-grand). 2001;47 Online Pub:OL49-50.

PMID:11936873

Abstract

Recently, Quintana and others published the results of TEM investigations of ferritin cores extracted from the brain tissue of patients suffering from progressive supranuclear palsy (PSP) and Alzheimer's disease (AD). These ferrihydrite (fFe2O3.9H2O) cores from the iron storage protein ferritin were found to contain a ferrous (Fe2+) iron-bearing biomineral with cubic structure similar to the magnetite standards which were measured. This is a highly important result as magnetic and electron microscopy analysis has demonstrated the presence of magnetite (Fe3O4) and maghemite (gammaFe2O3) in human brain tissue.

摘要

最近，金塔纳等人发表了对从进行性核上性麻痹（PSP）和阿尔茨海默病（AD）患者脑组织中提取的铁蛋白核心进行透射电子显微镜（TEM）研究的结果。这些来自铁储存蛋白铁蛋白的水铁矿（fFe2O3·9H2O）核心被发现含有一种具有立方结构的含亚铁（Fe2+）的生物矿物，其结构与所测量的磁铁矿标准相似。这是一个非常重要的结果，因为磁性和电子显微镜分析已经证明人脑组织中存在磁铁矿（Fe3O4）和磁赤铁矿（γFe2O3）。