Schmidt N J, Forghani B, Lennette E H
Infect Immun. 1975 Oct;12(4):728-32. doi: 10.1128/iai.12.4.728-732.1975.
Studies comparing the enhancing effect of guinea pig complement on homotypic and heterotypic neutralizing antibodies produced in initial herpes simplex virus (HSV) infections of humans indicated that antibodies to HSV type 1 and HSV type 2 were enhanced to about the same extent, and there was no signigicant difference in the degree to which complement enhanced homotypic and heterotypic HSV-neutralizing antibody. Homotypic and heterotypic immunoglobulin G neutralizing antibodies were enhanced by complement to as great, or greater, an extent as immunoglobulin M (IgM) HSV antibodies in the same sera. In patients with initial HSV type 1 infections, the IgM neutralizing antibody response was type specific. On the other hand, patients with initial HSV type 2 infections produced both homotypic and heterotypic IgM neutralizing antibody. An initial HSV type 2 infection in an individual previously infected with HSV type 1 elicited the production of IgM neutralizing antibody to both HSV type 1 and HSV type 2. However, patients with recurrent HSV type 1 infections failed to produce IgM antibody to either HSV type during reactivation of the virus.
比较豚鼠补体对人类初次单纯疱疹病毒（HSV）感染产生的同型和异型中和抗体增强作用的研究表明，针对1型HSV和2型HSV的抗体增强程度大致相同，补体增强同型和异型HSV中和抗体的程度没有显著差异。在同一血清中，同型和异型免疫球蛋白G中和抗体被补体增强的程度与免疫球蛋白M（IgM）HSV抗体相同或更高。在初次感染1型HSV的患者中，IgM中和抗体反应具有型特异性。另一方面，初次感染2型HSV的患者产生了同型和异型IgM中和抗体。先前感染过1型HSV的个体初次感染2型HSV会引发针对1型HSV和2型HSV的IgM中和抗体的产生。然而，复发性1型HSV感染患者在病毒重新激活期间未能产生针对任何一种HSV型别的IgM抗体。
