Iwata Hisashi, Sakano Shinji, Itoh Takayasu, Bauer Thomas W
Department of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya, Japan.
Clin Orthop Relat Res. 2002 Feb(395):99-109. doi: 10.1097/00003086-200202000-00010.
The recognition that demineralized bone matrix could induce bone formation when placed in mammalian skeletal muscle led to preclinical studies of crude native insoluble bone morphogenetic protein and noncollagenous protein, followed by the clinical application of demineralized bone matrix, chemosterilized autolyzed antigen-extracted allogenic bone, and autolyzed antigen-extracted allogenic bone matrix gelatin. Cultural norms and regulatory agencies influence the availability of different demineralized bone matrix preparations in different parts of the world, but there is continued interest in the biologic structure of native insoluble bone morphogenetic protein and noncollagenous protein aggregates and the applied science of osteoinduction and osteoconduction in reconstructive orthopaedic surgery. Demineralized bone matrix is not widely available in Asia, but tissue processing facilities in the United States distribute demineralized bone matrix materials with different carriers, handling properties, and possibly osteoinductive potential. The purpose of the current study was to review the development and use of various preparations of demineralized bone matrix materials.
当脱矿骨基质置于哺乳动物骨骼肌中时可诱导骨形成，这一认识引发了对粗制天然不溶性骨形态发生蛋白和非胶原蛋白的临床前研究，随后脱矿骨基质、化学灭菌自溶抗原提取同种异体骨以及自溶抗原提取同种异体骨基质明胶被应用于临床。文化规范和监管机构影响着世界不同地区不同脱矿骨基质制剂的可获得性，但人们对天然不溶性骨形态发生蛋白和非胶原蛋白聚集体的生物学结构以及重建整形外科中骨诱导和骨传导的应用科学仍持续感兴趣。脱矿骨基质在亚洲并不广泛可得，但美国的组织处理设施会分发具有不同载体、处理特性以及可能具有不同骨诱导潜力的脱矿骨基质材料。本研究的目的是回顾各种脱矿骨基质材料制剂的发展和应用情况。
