Harel D, Sharf B, Bental E
Isr J Med Sci. 1975 Oct;11(10):986-90.
The activation by a short-acting barbiturate, methohexital, of spike and wave discharges in epileptic patients with normal EEG tracings was evaluated. Seventy-five patients and 20 healthy control subjects were studied. Non-specific changes--desynchronization, fast sharp activity and diffuse slowing--appeared in all the tracings. Only eleven patients had positive activation after methohexital administration. The results were not encouraging and indicate that methohexital is not reliable as a diagnostic tool in problematic cases of verified or suspected epilepsy with normal EEG tracings.
评估了短效巴比妥类药物美索比妥对脑电图记录正常的癫痫患者棘波和慢波放电的激活作用。研究了75例患者和20名健康对照者。所有记录中均出现了非特异性变化——去同步化、快速锐波活动和弥漫性减慢。仅11例患者在给予美索比妥后出现阳性激活。结果并不令人鼓舞，表明在脑电图记录正常的已证实或疑似癫痫的疑难病例中，美索比妥作为诊断工具并不可靠。
