Aasly J, Blom S, Silfvenius H, Zetterlund B
Acta Neurol Scand. 1984 Dec;70(6):423-31. doi: 10.1111/j.1600-0404.1984.tb00847.x.
Bilateral intracarotidal Amytal (amobarbital) tests for evaluation of speech and memory function were performed during preoperative evaluation of 30 patients with drug-resistant epilepsy. In 8 of these patients (16 tests), having partial complex epilepsy, EEG was recorded with depth electrodes, implanted bilaterally in anterior mesial temporal structures. The EEGs during 13 tests could be quantified with regard to spike activity. A rapid increase in spike frequency was observed ipsilateral to the injection in all tests but one. No seizure activity or clinical seizures were provoked. This previously unnoticed effect of amobarbital could be due to a direct excitatory effect of the drug on epileptic temporal neurones or, alternatively, to a release of interictal inhibition, exerted upon these neurons by other structures. In 4 patients, the effect was compared with that of methohexital, another barbiturate known to have excitatory effects upon epileptic activity.
在对30例耐药性癫痫患者进行术前评估期间，进行了双侧颈动脉注射阿米妥（异戊巴比妥）试验以评估言语和记忆功能。其中8例（16次试验）患有部分性复杂性癫痫的患者，在双侧前内侧颞叶结构中植入深度电极记录脑电图。13次试验期间的脑电图可根据棘波活动进行量化。除一次试验外，在所有试验中均观察到注射同侧的棘波频率迅速增加。未诱发癫痫活动或临床发作。阿米妥这种先前未被注意到的作用可能是由于该药物对癫痫性颞叶神经元的直接兴奋作用，或者是由于其他结构对这些神经元施加的发作间期抑制的释放。在4例患者中，将该效应与甲己炔巴比妥（另一种已知对癫痫活动有兴奋作用的巴比妥类药物）的效应进行了比较。
