Erdem Ahmet, Arslan Murat, Erdem Mehmet, Yildirim Gizem, Himmetoğlu Ozdemir
Department of Obstetrics and Gynecology, University of Gazi, School of Medicine, Beşevler, Ankara, Turkey.
Am J Perinatol. 2002 Feb;19(2):87-92. doi: 10.1055/s-2002-23559.
The aim of this study was to investigate whether there was a relationship between H. pylori (Helicobacter pylori) infection positivity and characteristics (time and duration) of hyperemesis gravidarum (HG) symptoms. Forty-seven pregnant women with HG and 39 pregnant controls at the same gestational weeks without any gastrointestinal symptoms were included in this prospective study. H. pylori serum Immunoglobulin (Ig) G concentrations were determined by enzyme-linked immunoadsorbent assay (ELISA) in patients with HG and controls. Positive serology for H. pylori was correlated with the duration of symptoms in patients with HG. The prevalence of H. pylori infection was 85.1% (40 of 47) and 64.1% (25 of 39) in patients with HG and controls, respectively (p <0.05, chi (2) test). Mean values of H. pylori IgG (+/- standard deviation) were significantly higher in patients with HG than in controls (22.66 aIU/mL +/- 22.34 vs. 11.54 aIU/mL +/- 13.89, p <0.01, Student's t-test). In HG group, time (gestational weeks) and the duration (weeks) of HG symptoms for patients serologically positive and negative for H. pylori were 6.95 +/- 1.55 versus 6.58 +/- 1.78 weeks, (p >0.05, Student's t-test) and 8.35 +/- 5.28 versus 11.40 +/- 7.17 weeks (p >0.05, Mann-Whitney U-test), respectively. There was no correlation between duration of HG symptoms and serum H. pylori IgG concentrations. Although a majority of pregnant women with HG were serologically positive for H. pylori infection, there was no correlation between positive serology and duration of symptoms, which is not suggestive of a direct causal relationship between H. pylori infection and HG.
本研究的目的是调查幽门螺杆菌（Helicobacter pylori）感染阳性与妊娠剧吐（HG）症状的特征（时间和持续时间）之间是否存在关联。本前瞻性研究纳入了47例患有妊娠剧吐的孕妇以及39例处于相同孕周且无任何胃肠道症状的妊娠对照组。通过酶联免疫吸附测定（ELISA）法测定妊娠剧吐患者和对照组的幽门螺杆菌血清免疫球蛋白（Ig）G浓度。幽门螺杆菌血清学阳性与妊娠剧吐患者的症状持续时间相关。妊娠剧吐患者和对照组中幽门螺杆菌感染的患病率分别为85.1%（47例中的40例）和64.1%（39例中的25例）（p<0.05，卡方检验）。妊娠剧吐患者的幽门螺杆菌IgG平均值（±标准差）显著高于对照组（22.66 aIU/mL±22.34 vs. 11.54 aIU/mL±13.89，p<0.01，Student氏t检验）。在妊娠剧吐组中，幽门螺杆菌血清学阳性和阴性患者的妊娠剧吐症状出现时间（孕周）和持续时间（周）分别为6.95±1.55周与6.58±1.78周（p>0.05，Student氏t检验）以及8.35±5.28周与11.40±7.17周（p>0.05，Mann-Whitney U检验）。妊娠剧吐症状的持续时间与血清幽门螺杆菌IgG浓度之间无相关性。虽然大多数妊娠剧吐孕妇的幽门螺杆菌感染血清学呈阳性，但血清学阳性与症状持续时间之间无相关性，这并不表明幽门螺杆菌感染与妊娠剧吐之间存在直接因果关系。
