妊娠剧吐中的幽门螺杆菌粪便抗原检测：是妊娠剧吐的危险因素吗？
Helicobacter pylori stool antigen assay in hyperemesis gravidarum: a risk factor for hyperemesis gravidarum or not?
作者信息
Aytac Sirin, Türkay Cansel, Kanbay Mehmet
机构信息
Department of Gastroenterology, Güven Hospital, Ankara, Turkey.
出版信息
Dig Dis Sci. 2007 Oct;52(10):2840-3. doi: 10.1007/s10620-006-9709-9. Epub 2007 Apr 12.
OBJECTIVE
To test the hypothesis that Helicobacter pylori (H. pylori) infection may cause hyperemesis gravidarum (HG).
MATERIALS AND METHODS
A prospective-comparative study was performed on 107 pregnant patients from October 2002 to December 2003 in a university-based prenatal care clinic. Blood and stool samples were obtained from 52 patients diagnosed as HG and 55 matched asymptomatic pregnant women. H. pylori stool antigen (HpSA) status of the participants was evaluated using a commercially available enzyme immunoassay-based kit.
RESULTS
The overall prevalence of HpSA positivity appeared as 41.1%. Twenty-two of 52 (42.3%) HG patients and 22 of 55 (40.0%) control subjects were positive for HpSA. The difference was not significant (p>.05).
CONCLUSION
HG seemed to be not associated with H. pylori infection, as indicated by specific stool antigen assay.
目的
检验幽门螺杆菌（H. pylori）感染可能导致妊娠剧吐（HG）这一假说。
材料与方法
2002年10月至2003年12月，在一所大学的产前护理诊所对107名孕妇进行了一项前瞻性比较研究。从52名被诊断为妊娠剧吐的患者和55名匹配的无症状孕妇中采集血液和粪便样本。使用市售的基于酶免疫测定的试剂盒评估参与者的幽门螺杆菌粪便抗原（HpSA）状态。
结果
HpSA阳性的总体患病率为41.1%。52名（42.3%）妊娠剧吐患者中的22名和55名（40.0%）对照受试者中的22名HpSA呈阳性。差异无统计学意义（p>0.05）。
结论
特定粪便抗原检测表明，妊娠剧吐似乎与幽门螺杆菌感染无关。
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