Melrose W, Pisters P, Turner P, Kombati Z, Selve B P, Speare R
School of Public Health and Tropical Medicine, James Cook University, Townsville, Australia.
P N G Med J. 2000 Sep-Dec;43(3-4):161-5.
During the period from 1991 to 1997 the School of Public Health and Tropical Medicine, James Cook University carried out filariasis surveys in several parts of Papua New Guinea using the newly introduced Onchocerca gibsoni monoclonal (Og4C3) and immunochromatographic test (ICT) antibody-based assays for filarial antigen and, in some cases, a Knott's test for microfilariae. The average prevalence of filarial antigenaemia and microfilaraemia was 56% and 35% respectively confirming earlier survey results that filariasis is hyperendemic in many parts of the country. The antigen tests detected 25% more cases than the Knott's test and the simplicity of the ICT and its capacity to produce almost instant results make it an ideal tool for surveys.
1991年至1997年期间，詹姆斯·库克大学公共卫生与热带医学学院在巴布亚新几内亚的多个地区开展了丝虫病调查，采用新引入的基于冈比亚丝虫单克隆抗体（Og4C3）和免疫层析试验（ICT）的丝虫抗原检测方法，在某些情况下还采用了用于检测微丝蚴的厚血膜法。丝虫抗原血症和微丝蚴血症的平均患病率分别为56%和35%，这证实了早期调查结果，即丝虫病在该国许多地区呈高度流行。抗原检测比厚血膜法多检测出25%的病例，ICT的简便性及其几乎能即时得出结果的能力使其成为调查的理想工具。
