Unité Mixte Internationale 233, Institut de Recherche pour le Développement and University of Montpellier 1, Montpellier, France; Programme National de Lutte contre l'Onchocercose, Ministère de la Santé et de la Population, Brazzaville, Republic of Congo; Filariasis and other Tropical Diseases Research Centre, Yaoundé, Cameroon; Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.
Am J Trop Med Hyg. 2013 Nov;89(5):916-8. doi: 10.4269/ajtmh.13-0245. Epub 2013 Sep 9.
Abstract. The value of a semi-quantitative scoring of the filarial antigen test (Binax Now Filariasis card test, ICT) results was evaluated during a field survey in the Republic of Congo. One hundred and thirty-four (134) of 774 tests (17.3%) were clearly positive and were scored 1, 2, or 3; and 11 (1.4%) had questionable results. Wuchereria bancrofti microfilariae (mf) were detected in 41 of those 133 individuals with an ICT test score ≥ 1 who also had a night blood smear; none of the 11 individuals with questionable ICT results harbored night mf. Cuzick's test showed a significant trend for higher microfilarial densities in groups with higher ICT scores (P < 0.001). The ICT scores were also significantly correlated with blood mf counts. Because filarial antigen levels provide an indication of adult worm infection intensity, our results suggest that semi-quantitative reading of the ICT may be useful for grading the intensity of filarial infections in individuals and populations.
摘要。在刚果共和国的实地调查中，评估了丝虫抗原检测（Binax Now 丝虫病卡片检测，ICT）结果的半定量评分的价值。在 774 次检测中，有 134 次（17.3%）明显呈阳性，并被评为 1、2 或 3 分；11 次（1.4%）有可疑结果。在 133 名 ICT 检测评分≥1 且夜间血涂片也有微丝蚴的个体中，有 41 人检测到班氏吴策线虫微丝蚴（mf）；在 11 名 ICT 结果可疑的个体中，均未发现夜间 mf。Cuzick 检验显示 ICT 评分较高的组微丝蚴密度呈显著增高趋势（P<0.001）。ICT 评分与血 mf 计数也呈显著相关。由于丝虫抗原水平表明成虫感染强度，我们的结果表明，ICT 的半定量读数可能有助于对个体和人群的丝虫感染强度进行分级。
